Clinical Implementation of 3D Printing in the Construction of Patient Specific Bolus for Photon Beam Radiotherapy for Mycosis Fungoides

Mycosis fungoides (MF), also known as Alibert-Bazin syndrome or granuloma fungoides, are a common subset of cutaneous T-cell lymphoma, with peak incidence in the 55~60 years age range. Radiation therapy is the most effective treatment method of MF, these dramatic responses of low dose X-ray therapy to MF were reported by Sholtz in 1902. Radiation therapy induces cell death predominantly by apoptosis in hematopoietic lineages, and is able to achieve complete response (CR) at a much lower dose compared to solid cancers. Since electrons penetrate much lesser than X-rays, MF is commonly treated with electron-beam therapy. Even though electron beam has many advantages over photon beam, treating irregular surfaces, such as finger or feet, with electron beam cause inadequate tumor coverage and excess dose. Therefore, irregular surface is treated Progress in Medical Physics 28(1), March 2017 https://doi.org/10.14316/pmp.2017.28.1.33 pISSN 2508-4445, eISSN 2508-4453